We are interested in using polymer-based nanomedicine to promote scientific knowledge in cancer treatment. Preclinical protocols spanning from test-tube evaluation to animal models will provide the proof of principal for any future approaches.
Our lab integrates nanotechnology, imaging science, gene therapy and cancer biology. Based on pharmaceutical sciences, we provide solutions on drug delivery using modern or more traditional approaches, in order to improve pharmacokinetic, biodistribution and absorption, water solubility and efficacy for smaller and bigger molecules. We expand to mechanistic studies of compounds and nucleic acids, for gene regulation and treatment on a panel of diseases.
With thousands of compounds in the preclinical pipeline, most of them limited by high lipophilicity, rapid elimination/metabolism, low absorption or unfavorable biodistribution profiles, we apply drug delivery methodology using dosage formulation techniques and nanotechology. While targeted delivery is steadily being recognized as a key ingredient for successfully delivering molecules to the desired tissue and cell, the possible applications have exponentially increased.
Our overarching goals are:
- To generate approaches that combine gene therapy with traditional chemotherapy to overcome chemoresistance and inhibit metastasis.
- To develop effective and safe agents for the treatment of prevalent human cancers such as pancreatic, colon, skin, breast, and lung cancer
- To improve drug targeting utilizing single or dual targeted nanomedicines, by recognizing the dynamic tumor microenvironment and cancer biology.
-To promote student oriented research to help young scientists transition from the undergraduate to graduate level and beyond with knowledge in analytical methodology, gene therapy and cancer treatment approaches.
Our immediate research projects involve:
1) The use of siRNAs or miRNAs to regulate gene expression of key ani-apoptotic genes to inhibit chemoresistance and metastasis in lung and pancreatic cancer.
2) Utilization of nanotechnology for targeted delivery
3) Formulation design for crossing the Blood Brain Barrier and treatment of glioblastoma multiform for delivery of therapeutic compounds
Undergraduate and graduate students are always encouraged to contact us for training opportunities in our lab. PhD applicants with backgrounds in pharmacy, biology, chemistry, and chemical engineering, are encouraged to reach out for position openings.