PUBLICATIONS

  • Hossian AKMN, Zahra F, Poudel S, Abshire C, Polk P, Garai J, Zabaleta J, Mikelis CM, and Mattheolabakis G., Advanced Bioinformatic Analysis and Pathway Prediction of NSCLC Cells upon Cisplatin Resistance, Scientific Reports, 2021, 10.1038/s41598-021-85930-y

  • Singh S, Mattheolabakis G, Gu X, Withers S, Dahal A, Jois S, A Grafted Peptidomimetic for EGFR Heterodimerization Inhibition: Implications in NSCLC Models, European Journal of Medicinal Chemistry, 2021 (in press)

  • Hossian AKMN, Mackenzie GGM, and Mattheolabakis G, Combination of miR-143 and miR-506 reduces lung and pancreatic cancer cell growth through the downregulation of cyclin-dependent kinases, Oncology Reports, 2021;45(4):2. doi: 10.3892/or.2021.7953

  • Hossian AKMN, Jois S, Jonnalagadda SC, and Mattheolabakis G, Nucleic acid delivery with α-tocopherol-Polyethyleneimine-Polyethylene glycol nanocarrier system, International Journal of Nanomedicine, 2020, doi:10.2147/IJN.S259724
     

  • Shrestha L, Singh S, Parajuli P, Dahal A, Mattheolabakis G., Mayer S, Jois S, In vivo studies of a peptidomimetic that targets EGFR dimerization in NSCLC, Journal of Cancer 2020, Vol. 11; doi:10.7150/jca.46320
     

  • Mattheolabakis G, Constantinos MM, Nanoparticle delivery and tumor vascular normalization: the chicken or the egg? Frontiers of Oncology, November 2019, 10.3389/fonc.2019.01227
     

  • Hossian A, Mackenzie G, Mattheolabakis G, miRNAs in Gastrointestinal diseases: Can we effectively deliver RNA-based therapeutics orally? Nanomedicine, 18 Nov 2019, https://doi.org/10.2217/nnm-2019-0180
     

  • Caceres J, Munoz-Sagastibelza M, Hossian A, Paredes J, Barrera K, Mattheolabakis G, Martello A, Vignesh S, Evaluation of the feasibility of intrapancreatic delivery of drug-loaded microparticles via endoscopic ultrasound fine-needle injection using a swine model, Endoscopy International Open, 2019, Aug;7(8):E1008-E1017. doi: 10.1055/a-0953-2070. Epub 2019 Aug 8.
     

  • Hossian A, Sajib M, Tullar P, Mikelis C, Karen Briski, Mattheolabakis G, Analysis of combinatorial miR treatments to regulate Cell Cycle and Angiogenesis, Accepted – JoVE, 2019; (145), e59460, doi:10.3791/59460

  • Hossian A, Sajib M, Tullar P, Mikelis C, Mattheolabakis G, Multipronged activity of combinatorial miR-143 and miR-506 inhibits Lung Cancer cell cycle progression and angiogenesis in vitro, Scientific Reports, 2018, doi: 10.1038/s41598-018-28872-2

  • Labatut A, Mattheolabakis G, Non-Viral Based miR Delivery and Recent Developments, European Journal of Pharmaceutics and Biopharmaceutics, 2018, 10.1016/j.ejpb.2018.04.018

  • Guorgui J., Wang R., Mattheolabakis G., Mackenzie G., Curcumin formulated in solid lipid nanoparticles has enhanced efficacy in Hodgkin’s lymphoma in mice, Archives of Biochemistry and Biophysics, 2018, doi: 10.1016/j.abb.2018.04.012

  • Mattheolabakis  G., Wang R., Rigas B. and Mackenzie G.G., Phospho-valproic acid inhibits pancreatic cancer growth in mice: enhanced efficacy by its formulation in poly-(L)-lactic acid-poly(ethylene glycol) nanoparticles, International Journal Of Oncology, 2017;doi: 10.3892/ijo.2017.4103. PubMed PMID: 28849098

  • Mattheolabakis G, Ling D, Ahmad G, Amiji M., Enhanced Anti-Tumor Efficacy of Lipid-Modified Platinum Derivatives in Combination with Survivin Silencing siRNA in Resistant Non-Small Cell Lung Cancer, Pharm Res. 2016 Aug 15
     

  • Berman M, Mattheolabakis G, Suresh M, Amiji M, Reversing epigenetic mechanisms of drug resistance in solid tumors using targeted microRNA delivery, Expert Opin Drug Deliv. 2016 Apr 29:1-12
     

  • Ryo Hotta, Lily Cheng, Hannah K. Graham, Nandor Nagy, Jaime Belkind-Gerson, George Mattheolabakis, Mansoor M. Amiji, and Allan M. Goldstein, Delivery of enteric neural progenitors with 5-HT4 agonist-loaded nanoparticles and thermosensitive hydrogel enhances cell proliferation and differentiation following transplantation in vivo, Biomaterials, 2016 May; 88:1-11
     

  • Salzano G, Costa DF, Sarisozen C, Luther E, Mattheolabakis G, Dhargalkar PP, Torchilin VP, Mixed Nanosized Polymeric Micelles as Promoter of Doxorubicin and miRNA-34a Co-Delivery Triggered by Dual Stimuli in Tumor Tissue., Small. 2016 Jul 19. doi: 10.1002/smll.201600925
     

  • Amit Singh, Jing Xu, George Mattheolabakis, and Mansoor Amiji, Redox-Responsive EGFR-Targeted Gelatin Nanoparticles for Combination wt-p53 Plasmid DNA and Gemcitabine Treatment in Pancreatic Cancer Cells, Nanomedicine. 2015 Dec 3. pii: S1549-9634(15)00217-8. doi: 10.1016/j.nano.2015.11.010
     

  • Lara Milane, Amit Singh, George Mattheolabakis, Megha Suresh, and Mansoor M. Amiji, Exosome Mediated Communication within the tumor microenvironment, J Control Release. 2015 Jul 1. pii: S0168-3659(15)30001-8. doi: 10.1016/j.jconrel.2015.06.029.
     

  • George Mattheolabakis, Lara Milane, Amit Singh, Mansoor Amiji, Hyaluronic Acid Targeting of CD44 for Cancer Therapy: From Receptor Biology to Nanomedicine, (Invited review for Special Issue in honor of dr. Langer). J Drug Target, 2015; 23(7–8): 605–618
     

  • Huyen Tran, George Mattheolabakis, Hibah Aldawsari, and Mansoor Amiji. Exosomes as Nanocarriers for Immunotherapy of Cancer and Inflammatory diseases, Clin Immunol. 2015 Apr 2, pii: S1521-6616(15)00124-2. doi: 10.1016/j.clim.2015.03.021
     

  • George Mattheolabakis, Ioannis Papayannis, Jennifer Yang, Brandon M. Vaeth, Ruixue Wang, Nengtai Ouyang, Basil Rigas and Gerardo G. Mackenzie, Phospho-aspirin (MDC-22) prevents pancreatic carcinogenesis in mice, Cancer Prev Res(Phila). 2016 Jul; 9(7):624-34
     

  • Lauren E. Bartels, George Mattheolabakis, Joseph F. LaComb, Brandon M Vaeth1, Jizu Zhi, Basil Rigas and Gerardo G. Mackenzie, The novel agent phospho-glycerol-ibuprofen-amide (MDC-330) inhibits glioblastoma growth in mice: An effect mediated by cyclin D1, Carcinogenesis. 2016 Apr; 37(4):420-9
     

  • Wong, Chi; Cheng, Ka Wing; Papayannis, Ioannis; George Mattheolabakis; Huang, Liqun; Xie, Gang; Ouyang, Nengtai; Rigas, Basil, Phospho-NSAIDs have enhanced efficacy in mice lacking plasma carboxylesterase: Implications for their clinical pharmacology, Pharm Res. 2014 Nov 13
     

  • George Mattheolabakis, Chi C Wong, Yu Sun, Carol A Amella, Robert Richards, Panayiotis P. Constantinides, Basil Rigas, Pegylation improves the pharmacokinetics and bioavailability of small-molecule drugs hydrolysable by esterases: A study of phospho-ibuprofen, Journal of Pharmacology and Experimental Therapeutics, jpet.114.217208; published ahead of print July 21, 2014, doi:10.1124/jpet.114.217208
     

  • Ka Wing Cheng, Ting Nie, Nengtai Ouyanga, Ninche Alston, Chi C. Wong, George Mattheolabakis, Ioannis Papayannis, Liqun Huang, Basil Rigas. A novel ibuprofen derivative with anti-lung cancer properties: Synthesis, formulation, pharmacokinetic and efficacy studies, International Journal of Pharmaceutics, Oct 2014, doi:10.1016/j.ijpharm.2014.10.019
     

  • Gerardo G. Mackenzie, Liqun Huang, Ninche Alston, Nengtai Ouyang, Kvetoslava Vrankova, George Mattheolabakis, Panayiotis P. Constantinides, Basil Rigas, Targeting Mitochondrial STAT3 with the Novel Phospho-Valproic Acid (MDC-1112) Inhibits Pancreatic Cancer Growth in Mice, PLOS ONE, May 2013, Volume 8, Issue 5, e61532
     

  • Ka-Wing Cheng , Chi C. Wong , George Mattheolabakis , Gang Xie, Liqun Huang and Basil Rigas, Curcumin enhances the lung cancer chemopreventive efficacy of phospho-sulindac by improving its pharmacokinetics, Int J Oncol. 2013 Sep;43(3):895-902. doi: 10.3892/ijo.2013.1995. Epub 2013 Jun 27
     

  • George Mattheolabakis, Gerardo G. Mackenzie, Liqun Huang, Nengtai Ouyang, Ka Wing Cheng, Basil Rigas, Topically applied phospho-sulindac hydrogel is efficacious and safe in the treatment of experimental arthritis in rats, Pharmaceutical Research, March 2013, DOI 10.1007/s11095-012-0953-8
     

  • George Mattheolabakis, Basil Rigas and Panayiotis P. Constantinides, Nanodelivery Strategies in Cancer Chemotherapy: Biological Rationale and Pharmaceutical Perspectives, Nanomedicine, 2012 Oct; 7(10):1577-90
     

  • George E. Magoulas, Thomas Garnelis, Constantinos M. Athanassopoulos, Dionissios Papaioannou, George Mattheolabakis, Konstantinos Avgoustakis, Dimitra Hadjipavlou-Litinac, Synthesis and antioxidative/anti-inflammatory activity of novel fullerene–polyamine conjugates, Tetrahedron, 68, 35, 2 September 2012, 7041–7049
     

  • Ka Wing Cheng, George Mattheolabakis, C. C. Wong, Nengtai Ouyang, Liqun Huang, Panayiotis P. Constantinides and Basil Rigas, Topical phospho-sulindac (OXT-328) is effective in the treatment of non-melanoma skin cancer, International Journal of Oncology, 2012 Jul 27, DOI: 10.3892/ijo.2012.1577
     

  • Spiridoula Kyriakopoulou, George Mattheolabakis, Sofia Papadimitriou, Evangelos Karavas, Dimitrios Bikiaris and Konstantinos Avgoustakis, PPSu-PEG Copolymers and their Application in the Preparation of Cisplatin-loaded Nanoparticles, Current nanoscience, 2011, 7, 4, 503-509
     

  • George Mattheolabakis, Ting Nie, Panayiotis P. Constantinides, Basil Rigas, Sterically stabilized liposomes incorporating the novel anticancer agent phospho-ibuprofen (MDC-917): Preparation, characterization and in vitro/in vivo evaluation, Pharmaceutical Research, 2011, DOI: 10.1007/s11095-011-0619-y
     

  • Zacharoula Iatridi, George Mattheolabakis, Konstantinos Avgoustakis, and Constantinos Tsitsilianisa, Self-assembly and drug delivery studies of pH/thermo-sensitive polyampholytic (A-co-B)-b-C-b-(A-co-B) segmented terpolymers, Soft matter, 2011, 7, 23, 11160-11168
     

  • Alexandros A. Vassiliou, Sofia A. Papadimitriou, Dimitrios N. Bikiaris, George Mattheolabakis, Konstantinos Avgoustakis, Facile synthesis of polyester-PEG triblock copolymers and preparation of amphiphilic nanoparticles as drug carriers, Journal of Controlled Release, 148-3,  2010,  388-395
     

  • Bakandritsos A., George Mattheolabakis, Chatzikyriakos G., Szabo T., Tzitzios V., Kouzoudis D., Couris S., Konstantinos Avgoustakis, Doxorubicin Nanocarriers Based on Magnetic Colloids with a Bio-polyelectrolyte Corona and High Non-linear Optical Response: Synthesis, Characterization, and Properties, Advanced Functional Materials, 2011, 21, 8, 1465-1475
     

  • Blatsios G., Tzimas A., George Mattheolabakis, Panagi Z., Avgoustakis K., Gartaganis S., Development of biodegradable controlled release sclera systems of Triamcinolone acetonide, Current Eye Research, 2010, 35, 10,  916-924.
     

  • Bakandritsos A., George Mattheolabakis, Zboril R.,Bouropoulos N., Tucek J., Fatouros D., Avgoustakis K., Preparation, stability and cytocompatibility of magnetic/PLA-PEG hybrids, Nanoscale, 2010, 2, 564–572
     

  • George Mattheolabakis, Lagoumintzis G., Panagi Z.,Papadimitriou E., Partidos C. D., Avgoustakis K., Transcutaneous Delivery of a Nanoencapsulated Antigen: Induction of Immune Responses, Intern. J. of Pharm. 385, 2010, 187–193
     

  • George Mattheolabakis, Taoufik E., Haralambous S., Roberts M. L., Avgoustakis K., In vivo investigation of tolerance and antitumor activity of cisplatin-loaded PLGA-mPEG nanoparticles, E. J. Pharm. Biopharm., 2009, 71, 190–195
     

  • Gryparis, E. C., George Mattheolabakis, Bikiaris, D. and Avgoustakis, K. Effect of Conditions of Preparation on the Size and Encapsulation Properties of PLGA-mPEG Nanoparticles of Cisplatin, Drug Delivery, 2007, 14, 371–380